miR‑338‑3p mediates gluconeogenesis via targeting of PP4R1 in hepatocytes
نویسندگان
چکیده
منابع مشابه
Gluconeogenesis from Lactate in Rat Hepatocytes
1. In freshly prepared isolated rat liver cells there is a lag in gluconeogenesis from lactate. The magnitude of the lag increases with increasing lactate concentration. 2. The lag is virtually abolished by lysine. 3. A few other amino acids (tyrosine, arginine, asparagine, ornithine) and NH4Cl had effects similar to, but less pronounced than, lysine during the early stage of incubation. Lysine...
متن کاملInterrelationships between gluconeogenesis and ureogenesis in isolated hepatocytes.
or,-Cycloserine (5 to 10 mvl), when added to isolated hepatocytes, is shown to inhibit aspartate aminotransferase predominantly in the cytosol. At low concentrations (0.1 to 0.2 mu) it selectively inhibits alanine aminotransferase. Aminooxyacetate (0.5 mu) irreversibly inhibits all transaminase activity provided the inhibitor is added prior to substrate addition. Neither cycloserine nor aminoox...
متن کاملGluconeogenesis in hepatocytes isolated from the skipjack tuna (Katsuwonus pelamis)
Skipjack ~ U M (Karsuwonus pelamis) hepatocytes were isolated and determined to be viable based on ttypan blue exclusion, energy charge, and lactate dehydrogenase leakage. Trypan blue staining and red blood cell contamination were always less than 0.1 % , and lactate dehydrogenase leakage remained less than 1 % at 25°C for 10 h. The energy charge for freshly isolated cells ranged from 0.65 to 0...
متن کاملATF3 mediates inhibitory effects of ethanol on hepatic gluconeogenesis.
Increases in circulating glucagon during fasting maintain glucose balance by stimulating hepatic gluconeogenesis. Acute ethanol intoxication promotes fasting hypoglycemia through an increase in hepatic NADH, which inhibits hepatic gluconeogenesis by reducing the conversion of lactate to pyruvate. Here we show that acute ethanol exposure also lowers fasting blood glucose concentrations by inhibi...
متن کاملLinoleic acid stimulates gluconeogenesis via Ca /PLC, cPLA2, and PPAR pathways through GPR40 in primary cultured chicken hepatocytes
Han Na Suh, Huang Thi Huong, Chang Hun Song, Jang Hern Lee, and Ho Jae Han Department of Veterinary Physiology, Biotherapy Human Resources Center (BK21), College of Veterinary Medicine, Chonnam National University, Gwangju, Korea; Department of Obstetrics and Gynecology, Chosun University Medical School, Gwangju, Korea; and Department of Veterinary Physiology, College of Veterinary Medicine, Se...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Medicine Reports
سال: 2018
ISSN: 1791-2997,1791-3004
DOI: 10.3892/mmr.2018.9400